The Flexbox (flexible box) CSS layout module is still very new, and the not all web browsers support it, but it definitely has some great potential. The flex grid (flexbox grid) is basically an improved version of the float grid. Here are some nice resources to help you understand Flexbox:
Introduction to CSS3 FLEXBOX by W3SCHOOLS: Read
Building a Flexible Grid (Zurb framework and Flexbox): Read 22